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Region-Specific Tolerance Criteria for the Living Brain

ABSTRACT – Computational models of traumatic brain injury (TBI) can predict injury-induced brain deformation. However, predicting the biological consequences (i.e. cell death or dysfunction) of induced brain deformation requires tolerance criteria. Here, we present a tolerance criterion for the cortex which exhibits ...


Age-related changes in the striatal dopaminergic system in the living

KEY WORDS dopamine synthesis; D1 receptor; D2 receptor; transporter; positron emission tomography; monkey brain. ABSTRACT. In the present study, age- related changes in the striatal dopaminergic system were examined in the living brains of conscious young (6.2. 1.5 years old) and aged (20.2. 2.6 years old) ...


Subacute NO generation induced by Alzheimer's -amyloid in the

induced by Alzheimer's -amyloid in the living brain: reversal by inhibition of the inducible NO synthase. FASEB J. 14, 1485–1489 (2000). Key Words: amyloid peptide nitric oxide iNOS brain in vivo microdialysis. Amyloid peptide (A), the cleavage product of amyloid precursor protein, is the major constituent of the senile ...


Optical imaging of architecture and function in the living brain sheds

Brain Topography, Volume 5, Number 2, 1992. 71. Optical Imaging of Architecture and Function in the. Living Brain Sheds New Light on Cortical Mechanisms. Underlying Visual Perception. A. Grinvald*. Summary: Long standing questions related to brain mechanisms underlying perception can finally be resolved by direct ...


Visualizing unstained neurons in living brain slices by Infrared DIC

With a combination of infrared illumination, differential interference contrast (DIC) and image intensification by video, unstained living neurons have been visualized up to a depth of 50-100/zm in 300-/zm thick brain slices. Recording and application pipettes could be placed under visual guidance. When applied to slices ...


Calcium imaging in the living brain: prospects for molecular medicine

Aug 12, 2008 ... Calcium imaging in the living brain: prospects for molecular medicine. Nathalie L. Rochefort, Hongbo Jia and Arthur Konnerth. Institute of Neuroscience, Technical University Munich, Biedersteiner Str. 29, 80802 Munich, Germany. Calcium imaging has revolutionized the approaches for functional analyses ...


Chemical Heterogeneity of the Living Human Brain: A Proton MR

Chemical Heterogeneity of the Living Human Brain: A Proton MR. Spectroscopy Study on the Effects of Sex, Age, and Brain Region. Igor D. Grachev1 and A. Vania Apkarian. Department of Neurosurgery and Department of Neuroscience and Physiology,. SUNY Upstate Medical University, Syracuse, New York 13210.


Neuroinflammation in the living brain of Parkinson's disease

Neuroinflammation in the living brain of Parkinson's disease. Yasuomi Ouchia, *, Shunsuke Yagia, Masamichi Yokokurab, Masanobu Sakamotoc. aMolecular Imaging Frontier Research Center, bDepartment of Psychiatry, Hamamatsu University School of Medicine, Handayama, Higashi-ku, Hamamatsu 431-3192, Japan.


Spatiotemporal dynamics of dendritic spines in the living brain

May 9, 2014 ... We believe that better understanding of the spatiotemporal patterns of spine dynamics will help elucidate the principles of experience-dependent circuit modification and information processing in the living brain. Keywords: dendritic spine, in vivo, two-photon imaging, experience-dependent plasticity, neural ...


Transcranial Two-Photon Imaging of the Living Mouse Brain

Introduction. The imaging of neurons, glia, and vasculature in the living brain has become an important experimental tool for understanding how the brain works. Transcranial two-photon laser scanning microscopy. (TPLSM) imaging of the cortex in living mice is a minimally invasive method that allows repeated imaging of ...


Serotonin 1A receptors in the living brain of Alzheimer's disease

Jan 17, 2006 ... Serotonin 1A receptors in the living brain of Alzheimer's disease patients. Vladimir Kepe*, Jorge R. Barrio*†, Sung-Cheng Huang*, Linda Ercoli‡, Prabha Siddarth‡, Kooresh Shoghi-Jadid*,. Gregory M. Cole§, Nagichettiar Satyamurthy* , Jeffrey L. Cummings¶, Gary W. Small‡, and Michael E. Phelps*†.


Biophotonics: Bringing the living brain into focus

OLIVER GRAYDON. BIOPHOTONICS. Bringing the living brain into focus. A fast scanning light-sheet microscope that produces multicolour, dynamic images of living tissue could provide fresh insights into the brain's neural circuits. Alexander D. Corbett and Gil Bub. The ability to record the micrometre-scale neural circuitry.


Visualizing the Living Human Brain

Visualizing the Living Human Brain. The Techniques and Promise of EEG and Event-Related Potentials. Mapping. Bernd Saletu. Department of Psychiatry, University of Vienna, Austria. Mapping of the electroencephalogram (EEG) and event-related potentials. (ERP) are readily and widely available, low cost, non- invasive, ...


Functional ultrasound imaging of intrinsic connectivity in the living

Oct 3, 2014 ... connectivity in the living rat brain with high spatiotemporal resolution. Bruno-Fйlix Osmanski1,2,3,*, Sophie Pezet4,5,*, Ana Ricobaraza4,5, Zsolt Lenkei4,5,** & Mickael Tanter1,2,3,**. Long-range coherences in spontaneous brain activity refiect functional connectivity. Here we propose a novel, highly ...


Localization of 5-HT1AReceptors in the Living Human Brain Using

Serotonergic 5-hydroxytryptamine-1A (5-HT,A) receptors are of interest in the pathophysiology of several neuropsychiatrie disor ders such as anxiety, depression and schizophrenia. [Carbonyl-. 11C]WAY-100635has recently been shown to be suitable for quantitative determination of 5-HT1Areceptors in the human brain.


The Missouri Greenbook Living with Brain Injury

The Missouri Greenbook. Living with Brain Injury. “Don't give up. As a survivor for over 10 years,. I experience continual progress every day.” - A guide for survivors , families and caregivers -. - Andrea Buening, Seneca, Mo. TBI survivor ...



Jul 28, 2007 ... Advance Access publication 28 July 2007 doi:10.1093/alcalc/agm059. ETHANOL OXIDATION IN THE LIVING BRAIN. SERGEY M. ZIMATKIN. ∗ and ALEXANDER L. BUBEN. Grodno State Medical University, Grodno, 230015, Belarus. ( Received 30 June 2006; first review notified 1 August 2006; in revised ...


Sodium ion apparent diffusion coefficient in living rat brain

Sodium Ion Apparent Diffusion Coefficient in Living. Rat Brain. James A. Goodman,1 Christopher D. Kroenke,2 G. Larry Bretthorst,2. Joseph J. H. Ackerman,1,2,3 and Jeffrey J. Neil2,4*. The apparent diffusion coefficient (ADC) of Na was determined in live rat brain. The brain extracellular-to-intracellular Na con- tent ratio is ...


Imaging of Neurotransmitter Receptors in the Living Human Brain

Jul 10, 2017 ... potential, since this technique makes it possible to examine biochemical and physiological events in the brain of living human subjects. Methods for the determination by PET of blood flow and glucose and oxygen consumption have now been available for several years.4 The study by PET of neuroreceptor ...


Living With Brain Cancer | The Brain Tumour Charity

Living with cancer especially a brain tumour can mean there may be areas of your life you have to think about which you have not considered before.