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Vascular Injury Induces Posttranscriptional Regulation of the Id3 Gene
Abstract—The molecular mechanisms that regulate the proliferation of smooth muscle cells (SMCs) of the vasculature in response to injury are poorly understood. Members of the inhibitor of DNA binding (Id) class of helix-loop-helix transcription factors are known to regulate the growth of a variety of cell types; however, the ...
Repair of Arterial Injury after Blunt Trauma in the Upper Extremity
Dec 7, 2009 ... Upper limb;. Artery;. Arterial repair;. Trauma;. Blunt;. Outcome. Abstract. Objective: In contrast to upper extremity stab and gunshot wounds, data on management and ... for Vascular Surgery. Published by Elsevier Ltd. All rights reserved. ... from stab or gunshot injuries (see Table 1),2e16 and outcome ...
Cytomegalovirus infection induces vascular injury in the rat
0 1992 Elsevier Scientific Publishers Ireland, Ltd. All rights reserved 0021-9150/ 92/$05.00 ... Cytomegalovirus infection induces vascular injury in the rat ..... 2e). Red blood cells were often present between the adherent leukocytes or in clusters which were randomly spread over the aortic intima (Fig. 2f); this phe- nomenon ...
Role of Asymmetric Dimethylarginine in Vascular Injury in
Jul 20, 2007 ... II–activated conditions, ADMA serves to contribute to the development of vascular injury and increased cardiac oxidative stress ..... fails to show a reduction in blood pressure in DDAH2 TG mice (Figure 2E). The difference between these 2 models may bear on the plasma ADMA levels in these 2 TG mice. In.
Angiopoietin-2 Facilitates Vascular Endothelial Growth Factor
necessary for the development of effective therapeutic strategies for ischemic brain injury. Vascular endothelial growth factor (VEGF) has been shown to ... Vascular endothelial growth factor (VEGF) is the most important factor in the regulation of the ... DOI: 10.1161/01.STR.0000170712.46106.2e. 1 by guest on November 5, ...
Vitronectin is up-regulated after vascular injury and vitronectin
We investigated the expression and the functional role of vitronectin (VN) in the response after vascular injury. Methods: VN and avb3/b5 integrin expressions were ..... 2E). throughout the media. Three days after carotid injury, the strong expression of VN in the SMC of the medial luminal. 3.1.3. Neointima side was correlated ...
Strain-Dependent Vascular Remodeling
Jul 13, 2004 ... Methods and Results—Recently, we established a mouse model of vascular remodeling based on partial ligation of the carotid, which is relevant ... DOI: 10.1161/01.CIR.0000134958.88379.2E. 220 ..... luminal stenosis after arterial injury in mice deficient for urokinase- or tissue-type plasminogen activator.
T Regulatory Lymphocytes Prevent Aldosterone-Induced Vascular
Thus, Tregs suppress aldosterone-mediated vascular injury, in part through effects on innate and adaptive immunity, suggesting that aldosterone-induced vascular damage could be prevented by an immunomodulatory approach. ( Hypertension. .... mesenteric arteries compared with control (Figure 2E and. 2F). This effect ...
Age-Dependent Impairment of Reendothelialization After Arterial Injury
Jan 21, 2003 ... Background—The mechanisms responsible for the association between advanced age and atherosclerotic diseases are not clear. Because atherosclerosis develops in response to local endothelial injuries, we investigated the effect of aging on vascular healing and reendothelialization. Methods and ...
Mineralocorticoid Receptor Antagonism Attenuates Vascular
kinase B activation is critical to vascular homeostasis via regulation of cell survival and expression of apoptotic genes. Protein kinase B ... MR antagonism protects the vasculature from aldosterone-induced vascular apoptosis and structural injury via rescuing .... 2E, and 2F, respectively) of NADPH oxidase compared with.
Plasminogen Activator Inhibitor Type 1 Enhances Neointima
Jun 26, 2001 ... Background—Plasminogen activator inhibitor type 1 (PAI-1) inhibits neointima formation after vascular injury. Hyperlipidemia modulates ... Conclusions—In atherosclerosis-prone mice, PAI-1 promotes neointima formation after oxidative vascular injury. The apparent .... in neointima (Figure 2E). Anti-BrdU ...
Title Platelet Factor 4 Mediates Vascular Smooth Muscle Cell Injury
Apr 8, 2013 ... Platelet Factor 4 Mediates Vascular Smooth Muscle Cell Injury Responses ... platelets and PF4 in vascular smooth cell injury responses both in vitro and in ..... 2E). However, after day 5 plasma IL-6 was not significantly different at any point between IL-6-/- and WT bone marrow mice (Fig. 2E). These data.
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Genetic targeting of sprouting angiogenesis using Apln-CreER
Jan 19, 2015 ... Interestingly, when blood flow was partially re-established at 2 weeks after injury (Fig. 2e), the number of APLN+ vascular ECs decreased (Fig. 2f), consistent with previous work showing that Apln expression is a reliable readout of hypoxia. We next administered tamoxifen 2 weeks after injury, to assay ...
Unique remodeling processes after vascular injury in intracranial
Apr 10, 2013 ... To address this issue, we established a novel vascular injury model in the intracranial .... 2013 ISCBFM All rights reserved 0271-678X/13 $32.00 .... on the intraluminal side of the injured arteries (Supplementary. Figure 2E). On day 14, neointimal hyperplasia began to form. (Figure 2G, red arrow). On day 28 ...
Inhibition of intimal hyperplasia after balloon injury in rat carotid
2001 Nature Publishing Group All rights reserved 0969-7128/01 $15.00 ... after vascular injury. We hypothesized that synthetic double- stranded DNA with high affinity for NFkB may be introduced as a 'decoy' cis element to bind the transcription factor, and block gene .... fected vessels (Figure 2e; n = 10 for each group, P.
Health surveillance - Guidance for Occupational Health Professionals
Neurological symptoms of HAVS include numbness and tingling in the fingers, and a reduced sense of touch and temperature. This nerve damage can be disabling, making it difficult to feel, and to work with, small objects. Vascular component. Episodic finger blanching is the characteristic vascular sign. This is sometimes.
Three-Year Delayed Presentation of Femoral Pseudoaneurysm after
Trauma to the wall of the artery may lead to the develop- ment of a pseudoaneurysm.1 Delayed presentation of lower limb pseudoaneurysms secondary to pene- trating trauma are particularly rare with only 8 cases reported in the literature.2e5. After presentation of this ... 2015 Elsevier Inc. All rights reserved. Manuscript ...
Science Journals — AAAS
Nov 22, 2017 ... such as angioplasty, stenting, or vascular surgeries in CKD patients. (2, 5–7). Vessel wall factors are critical triggers for the postvascular injury thrombosis, where denuded endothelium and exposed vascular smooth muscle cells (vSMCs ) create a highly reactive vascular bed. Tissue factor. (TF), a potent ...
Andrew J. Morris and Susan S. Smyth Christopher End, Christopher
Aug 14, 2008 ... Phone: 410-528-4050. Permissions: Permissions & Rights Desk, Lippincott Williams & Wilkins, a division of Wolters ... intimal hyperplasia, neither LPA1 nor LPA2 was required for dedifferentiation of SMCs following vascular injury .... a larger lumen area (Figure 2E), and a resulting increase in the.