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Needle free, oral vaccine delivery platform technology

Background: Immune Solutions Ltd (ISL) offers a novel oral delivery system to replace injections, aerosols, and patches. This US and internationally patented technology platform uses food-grade fatty acids in a tablet or paste to encapsulate and protect bacterial and viral vaccines and bio-actives. Significant success has ...


Novel Vaccine Delivery Technology

An oral live vaccine has been shown to protect pigs from illeitis (Kroll et al., 2004) and a corn-based delivery system is also promising for control of TGE (Lamphear et al., 2004). Another way to use DNA technology to improve vaccines for pigs is by developing adenovirus as a platform for a family of vaccines. The overall.


Polymer-grafted starch microparticles for oral and nasal immunization

Summary Microparticle delivery systems for oral vaccine administration are receiving considerable attention. A novel silicone polymer-grafted starch microparticle system was developed that is efficacious both orally and intranasally. Unlike most other microparticle systems, this novel system does not appear to retard the ...


Novel adjuvants & delivery vehicles for vaccines development: A

Novel adjuvants & delivery vehicles for vaccines development: A road ahead ... intranasal delivery of viral-vectors and proteosomes and oral delivery of VLP vaccines. ... vaccine design. Adjuvant and delivery system. An adjuvant is defined as any compound that enhances the immune response against a vaccine antigen .


Lectin-bearing Polymerized Liposomes as Potential Oral Vaccine

This establishes that lectin modification of liposomes can promote binding to Peyer's patches, which will give improved efficiency for Peyer's patch targeted delivery. All these point to the potential for these lectin-modified liposomes as novel vehicles for oral vaccination. lectin polymerized liposomes Peyer's patches surface ...


A comparison of anionic nanoparticles and microparticles as

Apr 10, 2007 ... The objective of this work was to conduct an in vivo comparison of nanoparticles and microparticles as vaccine delivery systems. Poly (lactide‑co‑glycolide) (PLG) polymers were used to create nanoparticles size 110 nm and microparticles of size 800–900 nm. Protein antigens were then adsorbed to these ...


Recent advances in the development of novel mucosal adjuvants

Nov 30, 2009 ... potential applications of several novel mucosal adjuvants and delivery systems: an archaeal lipid mucosal vaccine adjuvant and delivery (AMvAD) system, 3',5'- cyclic diguanylic acid ..... upon oral immunization.107 Recently, a recombinant protein with high affinity binding to Claudin 4 (a protein associated ...


Nanoparticulate Vaccine Delivery Systems Immune system. 15. Non-specific defense mechanism. 15. Specific defense mechanism. 16. 2.1.2 Immunoglobulins and Immune Response. 17. 2.1.3 Mucosal System. 20. 2.1.4 Mucosal Immune Response. 21. 2.2 Oral Route for Administration of Vaccines. 21. 2.3 Subcutaneous Delivery for Micro/ ...


Novel engineered systems for oral, mucosal and transdermal drug

Jun 12, 2013 ... 2013 Informa UK Ltd. DOI: 10.3109/1061186X.2013.805335. REVIEW. Novel engineered systems for oral, mucosal and transdermal drug delivery. Hairui Li1,2 ... need for researchers to look for novel drug delivery systems to increase ... vaccine showed their effectiveness in stimulating immune response in ...

130618 engineered.pdf

Novel Approaches for Oral Delivery of Macromolecules

system. Transcellular PathwaysThe intestinal epithelium rep- resents the largest interface (more then 200 m2) between the external environment and the internal .... pathways are theoretically available for oral delivery of drugs and vaccines because they do not require the presence of specific carriers for the transepithelial.


Landscape Analysis: Trends in Vaccine Availability and Novel

Jul 1, 2008 ... A landscape analysis has been undertaken to identify trends in the availability of vaccines and novel vaccine delivery ..... nervous system. ▫ Administration can be difficult to congested infants. ▫ Inhalation devices. ▫ IN delivery. Oral. ▫ Ease of administration. ▫ Needle-free administration. ▫ Mimics the natural ...


Novel polymer-grafted starch microparticles for mucosal delivery of

concept of a mucosal immune system in which mucosally situated. IgA and IgG plasma cell progenitors are stimulated selectively by mucosal immunization,3,4 and predict that mucosal immunization can provoke both mucosal and circulating antibody responses better than parenteral immunization. Oral vaccination ...


Oral Delivery of Vaccines

velopment of several novel 'antigen delivery' sys- tems which can be very efficient at inducing both secretory and systemic immunity following oral administration. These improved systems offer con- siderable promise for the future and may result in the development of new oral vaccines for clinical use. It is with these recent ...


Nanotechnology, Drug Delivery Systems and their Potential

Sep 11, 2015 ... recent advances in nanocarrier-based hepatitis B vaccine delivery systems. The challenges in the development ..... a live attenuated oral vaccine) and oral Polio vaccine (GlaxoSmithKline - a live attenuated oral ... novel nanoemulsion-based hepatitis B mucosal vaccine using a nanoemulsion manufactured ...


Pathogenicity Island 2 Mutants of Salmonella typhimurium Are

The potential use as vaccine delivery system of Salmonella typhimurium strains harboring defined mutations ... These novel S. typhimurium attenuated ...... Salmonella as carriers of heterologous antigens, p. 27–58. In D. T. O'Hagan (ed.), Novel delivery systems for oral vaccines. CRC Press, Inc., Boca Raton, Fla. 34.


Multilayer engineered nanoliposomes as a novel tool for oral

Apr 14, 2016 ... Aim: To develop an oral nanovaccine delivery system for lipopeptide-based vaccine candidate against group A Streptococcus. Materials & methods: Lipid- core peptide-. 1-loaded nanoliposomes were prepared as a template and coated with opposite- charged polyelectrolytes to produce particles with size ...


an overview of multifaceted significance of eudragit polymers in drug

Development of novel drug delivery system (NDDS) has been made ... wide applications in different drug delivery systems i.e. ophthalmic, buccal, sublingual, enteric, oral, colon, vaccine, gene, vaginal and transdermal drug delivery. ... fabrication of sustained release formulation and development of novel drug delivery ...


A Novel Drug Delivery System for DNA Vaccine for Hepatitis C Virus

Investigation of Functionalized Carbon Nanotubes as a Delivery. System for Enhanced Gene Expression with Implications in. Developing DNA Vaccines for Hepatitis C Virus. A Thesis. Submitted to the College of Graduate Studies and Research in Partial Fulfillment of the Requirements for the Degree of. Master of Science.


Targeted nanoparticles with novel non-peptidic ligands for oral

Feb 20, 2013 ... Targeted nanoparticles with novel non-peptidic ligands for oral delivery☆. Anne des Rieux a, Vincent ... nanoparticles could be promising vehicles for oral vaccination by targeting M cells or for the delivery of ther- .... delivery systems are administered orally, they are exposed to the harsh environment of the ...


Topical immunization: Mechanistic insight and novel delivery systems

Transcutaneous Immunization (TCI), is a novel and emerging method of vaccine delivery because it is safe and convenient. Moreover, skin is ... Keywords: topical immunization, transcutaneous immunization, novel delivery systems, liposomes, niosomes, transfersomes ... oral and nasal immunization can induce both serum.

IJBT 3(1) 9-21.pdf