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CD5 + B cells and CD4-8- T cells in neuroimmunological diseases

Key words: B cell, CD5-; T cell, CD4-8-; Neuroimmunological disease. Summary. Using 2- and 3-colour FACS analysis we found increased levels of fetal-type CD5 + B cells and. CD4-8- T cells in cerebrospinal fluid (CSF) of patients with multiple sclerosis (MS) and aseptic meningitis (AM) compared to control probands with ...


Glycoconjugates and Neuroimmunological Diseases

logical field. Keywords Gangliosides • Glycolipids • Autoantibody • Peripheral nerve •. Neuropathy. Chapter 25. Glycoconjugates and Neuroimmunological. Diseases. Hugh J. Willison. H. J. Willison (*). Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life. Sciences , University of Glasgow ...


Neuroimmunological Diseases Cerebrospinal Fluid Cells in Patients

We performed unbiased, comprehensive immunophenotyping of cerebrospinal fluid (CSF) and blood leukocytes in 221 subjects referred for the diagnostic work- up of neuroimmunological disorders to obtain insight about disease-specific phenotypes of intra- thecal immune responses. Quantification of 14 different immune ...


Fellowship program in Neuroimmunology

The major goal of this fellowship program is to produce specialists with the knowledge and tools to diagnose, treat and prevent immune-mediated disorders of the nervous system. The fellowship will provide board certified neurologists to train for 6-12 months in the clinical or basic science research skills and management of ...


Therapeutic complement inhibition: a promising approach for

Jan 12, 2017 ... neuroimmunological diseases. Kjara S Pilcha, Peter J Spaethb, Nobuhiro Yukic and Benjamin R Wakerleyd. aDepartment of Cell and Developmental Biology, University College London, UK; bUniversity of Bern, Institute of Pharmacology, Bern, Switzerland;. cDepartment of Neurology, University of Mishima ...


Mycophenolate mofetil and tacrolimus: New therapeutic options in

Mar 31, 2006 ... and now used increasingly in neuroimmunological diseases including my- asthenia gravis, dysimmune polyneuropathies, and myositis. In myasthenia gravis, the efficacy and safety of MMF has been shown by one open-label trial; one small, double-blind, placebo-controlled trial; and a few retrospec-.


Plasma Exchange in Neuroimmunological Disorders | Hematology

Plasma exchange is a well-established therapeutic procedure commonly used in many neurological disorders of autoimmune etiology. In this second part of our revi.


Epidemiology of neuroimmunological diseases

understanding these disorders, in particular in those diseases in which the pathogenesis has not been eluci- dated. This review focuses on the epidemiology of sev- eral neuroimmunological diseases such as inflamma- tory muscle disorders (polymyositis, dermatomyositis and inclusion body myositis), myasthenia gravis, im ...


Einsatz von Rituximab in der Behandlung neuroimmunologischer

Jan 29, 2009 ... Rituximab in treatment for neuroimmunological diseases. Summary. Rituximab, a human-mouse chimeric CD20 monoclonal antibody that depletes CD20-positive B cells, has already demonstrated efficacy in hematologic and rheumatologic diseases. Treatment with rituximab results in depletion of ...


Therapeutic apheresis in nephrology and neurology

disorders. In nephrology, plasmapheresis therapy can provide an approach by mechanically removing nephritogenic factors from the circulation, antibodies or immune complexes w4,5x. Plasma exchange has also been accepted as a treatment of patients with several neuroimmunological diseases. In several controlled.


How implementation of systems biology into clinical trials

Jun 27, 2014 ... 1 Neuroimmunological Diseases Unit, National Institute of Neurological Disorder and Stroke, National Institutes of Health, Bethesda, MD, USA. 2 Center for Human Immunology of the National Institutes of Health, Bethesda, MD, USA. 3 Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.


Therapeutic plasma exchange in neuro-immunological disorder

Feb 5, 2017 ... Therapeutic plasma exchange in neuro-immunological disorder. Aswin Kumar S. 1*, Latha B.2, Dhivya K.3. ABSTRACT. Background: Therapeutic plasma exchange (TPE) is an extracorporeal blood purification technique used to remove high molecular weight substances from the plasma. Examples of these ...


Use of intravenous gamma globulins in neuroimmunologic diseases

this therapy in neuroimmunologic diseases. In prospective, rig- orously controlled , double-blinded clinical trials, IVIg was found to have proven efficacy in the Guillain-Barré syndrome, chronic inflammatory demyelinating polyneuropathy, multifo- cal motor neuropathy, dermatomyositis, and Lambert-Eaton myasthenic ...


Certification Examination in Rare Neuroimmunologic Disorders

PURPOSES OF CERTIFICATION IN RARE NEUROIMMUNOLOGIC DISORDERS. Rare neuroimmunologic disorders are complex with potentially lifelong complications that affect many aspects of an individual's life. These rare autoimmune disorders of the central nervous system include Neuromyelitis. Optica Spectrum ...


The NeuroImmune Axis: Prospect for Novel Treatments for Mental

Abstract: Disturbed bidirectional pathways between the (central) nervous system and immune system have been implicated in various mental disorders, including depressive and neurodevelopmental disorders. In this minireview, the role of the neuro- immune axis and its targetability in relation to major depression and ...


Plasma Exchange in Neuroimmunological Disorders

Plasma Exchange in Neuroimmunological Disorders. Part 1: Rationale and Treatment of Inflammatory Central Nervous System Disorders. Helmar C. Lehmann, MD; Hans-Peter Hartung, MD; Gerd R. Hetzel, MD; Olaf Stüve, MD; Bernd C. Kieseier, MD. Plasma exchange is a well-established therapeutic procedure commonly ...


Neuroimmunological Processes in Parkinson's Disease and their

Cite this article as: Sanchez-Guajardo V, Barnum CJ, Tansey MG and Romero- Ramos M (2013) Neuroimmunological processes in Parkinson's disease and their relation to α-synuclein: microglia as the referee between neuronalprocesses and peripheral immunity. ASN NEURO. 5(2):art:e00112.doi:10.1042/ AN20120066.


Michal Schwartz is a Professor of Neuroimmunology, incumbent of

functional role for this neuroimmunological crosstalk for supporting immune surveillance of the healthy brain, and recruitment of immune cells which participate in CNS repair. Recent works of Schwartz's group describe dysregulation of this neuroimmunological crosstalk in brain aging and neurodegenerative diseases, with ...


Antibodies against glutamic acid decarboxylase: prevalence in

OND subgroup with sporadic progressive ataxia, but not in OND subgroups with recognised neuroimmunological diseases. In conclusion, increased GAD-Ab is nei- ther a non-specific epiphenomenon of neuronal damage nor a common feature of recognised neuroimmunological disor- ders. In neurological diseases, GAD- ...


The Myelin Mutant Rat Taiep as a Model of Neuroimmunological

Advances in Neuroimmune Biology 5 (2014) 9–17. DOI 10.3233/NIB-140081. IOS Press. 9. The Myelin Mutant Rat Taiep as a Model of Neuroimmunological Disease. Eguibar R. Josea,b,∗. , Cortes Ma. del Carmena, Ugarte Aracelia and León-Chávez Aliciac. aInstitute of Physiology, Benemérita Universidad Autónoma de ...