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WITH THE TARGET RNA IN SILICO—A PROGRESS. REPORT ON THE MECHANISM OF RNA CLEAVAGE. BY DNA ENZYME. 272. Oleksandr Plashkevych .... IL JOON LEE, Laboratory for Modified Nucleic Acid Systems, Department of .... Ramakrishnan of the Medical Research Council Laboratory of Molecular Biology.


Furan oxidation based cross-linking: a new approach for the study

Dec 1, 2015 ... Furan mediated nucleic acid cross-linking, initially developed for DNA interstrand duplex cross-linking, has matured into a ... shown that the methodology could be repurposed for RNA interstrand cross-linking, which is very relevant in ...... Technologies – Modified Nucleic Acids in Biology and Medicine, ed.


Chemical modification of nucleic acids as a key technology for the

RNA-based effector molecules (nucleic acid effectors) are important tools in molecular medicine because .... Chemical nucleic acid modifications are relevant to antisense ... biological miRNA effects are inhibition of the 5'-cap-dependent initiation of protein biosynthesis and/or induction of mRNA transfer into cytoplasmic ...


A Review of Peptide Nucleic Acid

Aug 31, 2015 ... a key role in molecular biology, genetic diagnostics and medicine [1]. Peptide Nucleic .... of the γ-position has found that γ-modification is more effectively improved ... Adv Tech Biol Med. ISSN: 2379-1764 ATBM, an open access journal affinity of PNA/DNA or PNA/RNA complexes is reflected in their higher.


Modifications on RNA–Spherical Nucleic Acid Conjugates and

Oct 20, 2016 ... INTRODUCTION. Spherical nucleic acids (SNAs) are a unique class of nanoparticles that typically consist of a dense layer of highly oriented oligonucleotides surrounding a nanoparticle (NP) core,1,2 and they exhibit several properties that make them attractive for biological and medical applications.


Innovative nucleic acid chemistry for industry and academia

Nucleic acids – the molecular building blocks of DNA and RNA - are at the heart of modern bioscience. Over several decades ... developed and commercialised a suite of innovative technologies based on chemically modified nucleic acids with ... chemistry and biology and highlights the need to continue to support future ...


Full Text (PDF)

Aug 14, 2017 ... aMinistry of Education Key Laboratory of Protein Sciences, Beijing Advanced Innovation Center for Structural Biology, Department of Basic Medical Sciences,. School of ... Chemical modifications on histones and DNA/RNA constitute a ... based surface plasmon resonance imaging (SPRi) technology for this.


Chemical Modifications of Nucleic Acid Aptamers for Therapeutic

Aug 2, 2017 ... Institute of Precision Medicine and Innovative Drug Discovery, School of Chinese Medicine, Hong Kong ... Abstract: Nucleic acid aptamers have minimal immunogenicity, high chemical synthesis production, ... modifications and technological advances that may enable early aptamers to be translated into.


What causes human cancer? Approaches from the chemistry of DNA

2013;35:88–92. 41. Loft S, Poulsen HE. Cancer risk and oxidative DNA damage in man. J Mol. Med. 1996;74:297–312. 42. Kasai H, Kawai K. 8-Hydroxyguanine, an oxidative DNA and RNA modification,. Modified Nucleic Acids in Biology and Medicine, RNA Technologies, Springer. International Publishing AG, in press.


Nucleic Acid Aptamers: Emerging Applications in Medical Imaging

Nov 16, 2017 ... modified triphosphates; medical imaging; drug delivery; gene regulation; DNA origami; ..... biological and neurological significance, an RNA aptamer was isolated against substance P [102]. Indeed, an ...... All the emerging applications described in this Review along with technological and synthetic.


Biology and Medicine

Mar 4, 2016 ... In the first approach, modified nucleotides are used for selecting aptamers in the process of library amplification. The main limitation of this method is incompatibility of a modified nucleotide with the DNA (RNA) polymerase, that is, inability of a nucleotide to act as a substrate for a ferment that catalyzes PCR.


Nucleic Acids Extraction from Formalin-Fixed and Paraffin

Technology & Medicine. Open Access ... hinders molecular biology tests since it fragments and chemically modifies nucleic acids, especially RNA. Although several studies describe techniques that allow extracting nu‐ cleic acids ... tion from FFPE tissue, compare the available protocols and to describe the modifications de‐.


Applications of Modern Proteomics in Biology and Medicine

art LC-MS technology. • Statistically rigorous data ... Precise measurement of proteins, their modifications and interaction partners is .... understanding through hypothesis-guided experiment. Protein-Protein (and disruption of these by small molecules). Protein-nucleic acid: DNA, RNA,. lincRNA. Protein-small molecule ...


Synthetic Biology Applying Engineering to Biology

Synthetic Biology. Applying Engineering to Biology. Report of a NEST High-Level Expert Group. NEST - New and Energing Science and Technology - is a research .... how genes and proteins modify each other's behaviour, for example, and how they interact to ... engineering disciplines, from medicine to energy generation.


RNAcentral: a comprehensive database of non-coding RNA

Oct 28, 2016 ... Campus, Hinxton, Cambridge CB10 1SD, UK, 2Faculty of Biology, Medicine and Health, University of Manchester,. Oxford Road ... Published by Oxford University Press on behalf of Nucleic Acids Research. This is an Open Access .... (23), a database of RNA modification pathways, as well as all ncRNA ...


Synthetic Chemically Modified mRNA (modRNA): Toward a New

eration of chemically modified mRNA (modRNA). ... species, and recent improvements in the core technology have supported moving toward ..... apeutic agent for cardiovascular biology and medicine, a number of specific challenges will. 0. 24. 48. 72. 96. 120. Time (h). Protein. DNA. modRNA. 144. 4. 3. 2. 1. 0. VEGF.


Nucleic acid crystallization and X-ray crystallography facilitated by

2 Howard Hughes Medical Institute, Department of Molecular Biology, and Center for Computational and Integrative Biology,. Massachusetts General ... crystallization solutions. Keywords selenium, DNA, RNA, nucleic acid, crystal- lization ... Se-atom-specific modified nucleic acid is referred as selenium nucleic acid (SeNA).


Novel Signal-Enhancing Approaches for Optical Detection of

Sep 23, 2015 ... Modern natural sciences and medicine actively apply nucleic acid detection in vitro, in cell culture ... assays like polymerase-chain reaction (PCR) and specific small interfering RNA (siRNA) knockdowns [1]. ... yielded limit of target detection ( LOD) values of 5 nM, which is not suitable for most biological.


Nucleic Acids as Therapeutics

ribonucleic acid, and micro ribonucleic acid. This chapter also includes current status of gene therapy and recent developments in gene therapy research. Keywords Gene therapy • Nucleic acid therapeutics • DNA-based therapeutics •. RNA-based therapeutics • Gene transfer technology • Viral vectors • Nonviral vectors • ...


2'-O-Methyl RNA/Ethylene-Bridged Nucleic Acid Chimera Antisense

Feb 10, 2017 ... Nikoniko House Medical and Welfare Center, Kobe 6511102, Japan; marikoyagi. [email protected] 4 ... Keywords: 2 -O,4 -C-ethylene-bridged nucleic acid; ENA; antisense oligonucleotide; exon skipping ... can stand further improvement in modification of nucleic acids, their delivery method, and evaluation.