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Cell Surface NADH Oxidases (ECTO-NOX Proteins) with Roles in

Cell Surface NADH Oxidases (ECTO-NOX Proteins) with. Roles in Cancer, Cellular Time-keeping, Growth, Aging and. Neurodegenerative Diseases. D. JAMES MORRÉa,* and DOROTHY M. MORRÉb. aDepartment of Medicinal Chemistry and Molecular Pharmacology, Hansen Life Sciences Research Building, West ...



Nov 13, 2017 ... “Cell Surface NADH Oxidases (ECTO-NOX Proteins) with Roles in Cancer, Cellular Time-Keeping,. Growth, Aging and Neurodegenera ve Diseases”. Free Rad. Res. Vol 37 (8); pp 795-808. 3. Morre et al (2007). “ECTO-NOX Target for the An cancer Isoflavene Phenoxodiol.” Oncol Res. Vol 16; pp 299-312.


(arNOX) Activity Correlated with Cartilage Degradation and Bony

demonstrate that OA itself is not a cause to increase arNOX activities, however, arNOX hyperactivity is related to a high ... Keywords: ENOX1 Protein, Human; Age-related NOX; Aging; Osteoarthritis; Cartilage. Min-Jung Kim,1* Hyun-Je Kim, 1 ..... ECTO-NOX proteins growth, cancer, and aging. New York, NY: Springer, 2013.


Gene Section

Homology. RNA recognition motif (RRM) in the cell surface. Ecto-NOX disulfide- thiol exchanger (ECTO-NOX or ENOX) proteins. This subgroup corresponds to ... Re-expression as an oncofetal protein helps explain the role of ENOX2 of cancer cells in acquiring the well-known characteristic of uncontrolled growth.


Molecular Cloning and Characterization of a Candidate Plant

Feb 2, 2015 ... ENOX1, ECTO-NOX Proteins, Plant Growth, Hydroquinone (NADH) Oxidation, Plasma Membrane ... The strictly periodic activity of the NOX proteins (ENOX1 and ENOX2 as well as arNOX) ... did not react with recombinant ENOX2 or with molecular species identified as ENOX2 from sera of cancer pa-.


Early Detection: An Opportunity for Cancer Prevention Through

Apr 20, 2012 ... Ecto-Nicotinamide Adenine Dinucleotide Oxidase Disulfide-Thiol Exchanger 2 ( ENOX2). (GenBank ... cancer. When the ENOX2 proteins are inhibited, as for example through EGCg/Capsicum synergies, the unregulated growth ceases and the cancer cells undergo programmed cell death (apoptosis).


Cancer Site-Specific Isoforms of ENOX2 (tNOX), A Cancer-Specific

All neoplastic cells express one or more members of a unique family of tumor- associated cell surface ubiquinone (NADH) oxidase proteins with protein disulfide-thiol interchange ... Cancer site-specific isoforms tNOX ENOX2 ECTO- NOX Pan ENOX2 recombinant antibody Two-dimensional gel electrophoresis Proteomics.


Age-Related Surface Oxidases Shed into Body Fluids as Targets to

Mar 3, 2014 ... around age 30 and increase steadily thereafter. Reduced quinones, i.e. ... Transmembrane Proteins; Serum and Body Fluids; Saliva; Skin Aging; Low Density Lipoproteins. 1. Introduction ... several species of ECTO-NOX (external NADH oxidases) or ENOX proteins that have been postulated to link.


Age-related NADH oxidase (arNOX) activity is significantly reduced

Jan 31, 2013 ... Age-related NADH oxidase (arNOX) is a cell surface protein shed into the circulation ... Sea urchins present an interesting model for investigating the process of aging since different ..... Morré DJ, Morré DM (2003) Cell surface NADH oxidases (ECTO-NOX proteins) with roles in cancer, cellular time-keeping, .


(ENOX1) in Saccharomyces cerevisiae

Keywords: Biological Clock; ECTO-NOX (ENOX). Proteins ... ECTO-NOX designates a family of cell surface proteins, exhibiting a ... A tumor-associated NAD. (P) H oxidase (ENOX2 or tNOX) is located on chromo- some Xq25-q26.2, and is restricted to the surface of cancer cells. Both have been identified within the human.


Benzo[b]thiophenesulphonamide 1,1-dioxide derivatives inhibit

Feb 1, 2005 ... British Journal of Cancer (2005) 92, 690–695. doi:10.1038/sj.bjc.6602383 www. bjcancer.com. Published ... Keywords: benzo[b]thiophenesulphonamides; antineoplasic drugs; ECTO-NOX; tumour-associated NADH oxidase; redox state ... protein has been proposed as the molecular target on cancer cells.


Cloning and Characterization of a Candidate Auxin Plant Growth

Dec 9, 2014 ... ENOX (ECTO-NOX) proteins of the external surface of the plasma membrane catalyze oxidation of ... A second ENOX activity designated tNOX or ENOX2 is tumor or cancer-associated [5] [6]. A third protein with ENOX-like activity ( designated arNOX) is age-related [7] and evident only in aged individuals, ...


Platelet surface glutathione reductase-like activity

dases (ECTO-NOX proteins) with roles in cancer, cellular time-keeping, growth, aging and neurode- generative diseases. Free Radic Res. 2003;37: 795-808. 11. Berridge MV, Tan AS. High-capacity redox control at the plasma membrane of mammalian cells: trans-membrane, cell surface, and serum NADH- oxidases.


Ultradian oscillators of the circadian clock in Saccharomyces

Feb 26, 2013 ... ECTO-NOX designates a family of cell surface proteins that exhibit ... activity is not inhibited by cyanide [8]. Also, ECTO-. NOX proteins have properties of prions, including stabil- ity, protease resistance and ability to form amyloid [9]. Although ... of cell growth and they are components of the biological clock.


Cancer prevention trial of a synergistic mixture of green tea

Jan 6, 2014 ... antibody to a cancer- specific and drug-responsive hydroquinone. (NADH) oxidase from the sera of cancer patients. Cancer Immunol. Immunother 2002, 51( 3):121–129. 9. Morré DJ, Morré DM: Cell surface NADH oxidases (ECTO-NOX proteins) with roles in cancer, cellular time-keeping, growth, aging and ...


The Oxidative Function of Diferric Transferrin

Nov 9, 2011 ... (ECTO-NOX proteins) with roles in cancer, cellular time- keeping, growth, aging and neurodegenerative diseases,” Free. Radical Research, vol. 37, no. 8, pp. 795–808, 2003. [18] T. Kishi, D. M. Morre, and D. J. Morre, “The plasma mem- brane NADH oxidase of HeLa cells has hydroquinone oxidase activity ...


Redox Signaling and Bioenergetics Influence Lung Cancer Cell

conformational changes associated with hydride transfer in proton-translocating transhydrogenase. Biochemistry 43:10952–10964. Morré DJ and Morré DM ( 2003) Cell surface NADH oxidases (ECTO-NOX proteins) with roles in cancer, cellular time-keeping, growth, aging and neurodegenerative diseases. Free Radic Res ...


Retbindin Is an Extracellular Riboflavin-binding Protein Found at the

Nov 6, 2014 ... riboflavin-binding protein of egg white. A kinetic and thermodynamic study. J. Biol . Chem. 257, 5607–5617. 39. Morré, D. J., and Morré, D. M. (2003) Cell surface NADH oxidases. (ECTO-NOX proteins) with roles in cancer, cellular time-keeping , growth, aging and neurodegenerative diseases. Free Radic.


Green tea phytocompounds as anticancer: A review

Apr 19, 2016 ... ECTO-NOX proteins: growth, cancer, and aging. New York: Springer; 2013, p. 507. [85] Tang X, Morre DJ, Morre DM. Antisense experiments demonstrate an exon 4 minus splice variant mRNA as the basis for expression of tNOX, a cancer- specific cell surface protein. Oncol Res 2007; 16(12): 557-67.


X‑linked congenital ptosis and associated intellectual disability

Dec 11, 2013 ... X-linked dominant condition: X-linked congenital isolated ptosis. am J Hum Genet 66:1455–1460. Morre DJ, Morre DM (2003) Cell surface naDH oxidases ( eCtO-. nOX proteins) with roles in cancer, cellular time-keeping, growth, aging and neurodegenerative diseases. Free radic res. 37:795–808. Pilia G ...