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The Global Cancer Genomics Consortium's Second Annual

and translational cancer research, aiming to meet the chal- lenges in cutting- edge cancer medicine. In the post–genome-sequencing era, next-generation approaches aiming to decipher the human genome, tran- scriptome, and proteome are increasingly finding potential roles in the diagnostics, prevention, and treatment of ...


Empirical Normalization for Quadratic Discriminant Analysis and

T. R. Golub, et al., "Molecular classification of cancer: class discovery and class prediction by gene expression monitoring," Science, vol. 286, p. 531, 1999. [9]. I. Jurisica, et al., "Cancer informatics in the post genomic era. Toward information- based medicine," Cancer treatment and research, vol. 137, p. 1, 2007. [10]. T. Ledl ...


Emerging landscape of genomics in the electronic health record for

Mar 10, 2011 ... Clinical and Translational Informatics, Dana-Farber Cancer Institute, Boston, Massachusetts. For the HVP ... We are entering into the genomic era of medicine, where a ..... Population-based registries, like those maintained for cancer, provide valuable data for clinical decision making, as well as research.


In Silico Prescription of Anticancer Drugs to Cohorts of 28 Tumor

Mar 9, 2015 ... Cancer Cell. Article. In Silico Prescription of Anticancer. Drugs to Cohorts of 28 Tumor Types. Reveals Targeting Opportunities. Carlota Rubio-Perez,1,4 David ... 1Biomedical Genomics Lab, Research Program on Biomedical Informatics, IMIM Hospital del Mar Medical Research Institute and Universitat.


Big Data: the challenge for small research groups in the era of

Oct 22, 2015 ... In the past decade, cancer research has seen an increasing trend towards high- throughput techniques and translational ... In this review, we highlight the Big Data challenges faced by translational research groups in the precision medicine era; ... potential to further personalise diagnosis and treatment.


Personalized Respiratory Medicine: Exploring the Horizon

Dec 22, 2014 ... prognostic information based on genomic and proteomic data, longitudinal studies of disease subtypes, and eventually more effective treatments based on tailored therapeutic regimens. Bottlenecks and. Opportunities. There are several biology/systems and medicine/PM research projects currently ongoing ...



Gene Discovery. DanuBiobank. 286 The Danubian Biobank Initiative — Towards. Information-based Medicine. Impacts. 288 Archive tissues: improving molecular medicine research and clinical practice. EpiGenChlamydia. 290 Contribution of molecular epidemiology and host- pathogen genomics to understand Chlamydia.



The complete sequencing of the Human Genome has opened, in this post- genomic era, new perspectives for ... in genomics. The Conference “Synergy between Research in Medical Informatics, Bioinformatics and ..... view or directions based on the flow of data and information attending to the disciplines in which they are ...


Clinical project management and operations in Post-Genomic Era of

which integrates genomics / combinatorial chemistry and modern informatics toward treatment of disease based on the underlying pathology and genetic polymorphism of the .... Precision Medicine versus. Personalized Medicine. Biomarker. 1http://www.biomarkersconsortium.org. 2NIH's National Cancer Institute (NCI) ...


Knaup: Towards Clinical Bioinformatics: Advancing Genomic

moved into a post-genomic era [3, 4]. Large scale genomic data are available and bio- medical informatics research provides the resources that can represent, analyse and visualize these data flexibly and efficiently. (e.g. [5-9]). The availability of genomic and proteomic information contributes to re- search in genomic ...


EpiGRAPH: A user-friendly software for advanced (epi-) genome

of personalized medicine. Epigenetic .... Typical application scenarios include the search for a diagnostic biomarker of early-stage colon cancer (based on ...... Jurisica, I, D Wigle,B Wong: Cancer informatics in the post genomic era: toward information-based medicine. 2007, New York ; London: Springer. xix, 180 p. 92.

Epigenetic biomarker development - postprint.pdf?OpenElement

Mutual understanding between Traditional Chinese Medicine and

1995 and did two-year postdoctoral work at the US National Cancer Institute. He was a Staff Scientist at Oak .... genome on the horizon, personalised medicine is actively pursued in biomedical research. Subtypes of diseases ... emphasises treatments based on personal conditions, including age, gender, personality, weight ...


Application of Bioinformatics in Cancer Research | SpringerLink

Nov 18, 2009 ... Abstract. Cancer is a disease determined by several genetic and epigenetic alterations. Due to technological advances in the omics disciplines, cancer research is going through a revolution. The technological advances that lead to the post-genome era have allowed molecular biologists to make ...


REVIEW Research Progress in Applying Proteomics Technology to

Proteomics Technology for Early Diagnosis Biomarkers of Breast Cancer, Lung Cancer, and Ovarian Cancer. Asian Pac J Cancer Prev, 15 (20), 8529-8538. Introduction. Proteomics has been widespreadly implanted into every field of life science and medicine as an important part of post-genomics era research. Proteomics ...


Toward Precision Medicine: Building a Knowledge Network for

Daniel Masys, Chair of the Department of Biomedical Informatics, Vanderbilt University. Medical Center. • William Pao, Director, Personalized Cancer Medicine at the Vanderbilt-Ingram Cancer. Center. • Erin Ramos, Epidemiologist, National Human Genome Research Institute. • Neil Risch, Institute for Human Genetics, ...


The National Cancer Program: Managing the Nation's Research

4 Provocative Questions. 8 Center for Cancer Genomics. 16 Introduction to Cancer Profiles. 18. Pancreatic Ductal Adenocarcinoma. 22. Colorectal Cancer. 26 ..... based diagnostics. These findings all lead toward “precision medicine,” an approach in which diagnoses are refined and treatments are custom-tailored based on ...


Personalized Health Care: Opportunities, Pathways, Resources

Sep 21, 2007 ... genomics • health information technology • evidence/clinical delivery. September 2007 ..... technology, can make possible a new kind of medical care for Americans: Personalized Health Care. .... In 1940, physicians identified cancer by the tissues in which it resided and had access to few treatment options ...


Synergy between medical informatics and bioinformatics: facilitating

Nov 23, 2004 ... ical informatics and bioinformatics: facilitating genomic medicine for future health care. Journal of. Biomedical Informatics ... Cancer Research Center. Heidelberg. Germany 15 ... The complete sequencing of the Human Genome has opened, in this post-genomic era, new perspectives for the study of ...


Resources for Interpreting Variants in Precision Genomic Oncology

Sep 19, 2017 ... 1 Center for Biomedical Informatics and Information Technology, National Cancer Institute, National Institutes of Health, ... Keywords: precision oncology, high throughput sequencing, genomic variation, cancer variants, precision medicine ... As with any clinical testing modality, whether in a research set-.


University of Cincinnati College of Medicine

College of Medicine. On the Cover. Eric Ramirez (SURF '11). University of Puerto Rico - Bayamon. Mentor: Nira Ben-Jonathan, PhD. Dept: Cancer and Cell ... THE RESEARCH. We are on the threshold of amazing scientific discoveries that promise greater progress than ever before. As we enter the post genome era, we  ...