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1 (P1NP and P1CP): molecular heterogeneity and assay technology. Pgs. 73–81. In: Bone Markers Biochemical and Clinical Perspectives. Eds. Eastell R, Baumann M,. Hoyle NR, Wieczorek L. Dunitz, London 2001. 9. Garnero P, Sornay-Rendu E, Duboeuf F, Delmas F. Markers of Bone Turnover Predict Postmenopausal.


Bone-turnover markers in fracture healing

Biochemical markers of bone-turnover have long been used to complement the radiological assessment of patients with metabolic bone disease. Their implementation in daily clinical practice has been helpful in the understanding of the pathogenesis of osteoporosis, the selection of the optimal dose and the understanding ...


Bariatric surgery and bone disease: from clinical perspective to

Jul 17, 2012 ... Bariatric surgery and bone disease: from clinical perspective to molecular insights ... between bariatric surgery and bone metabolism with emphasis on possible mechanisms of action such as malnutrition, hormonal interactions ...... rest on bone histology, biochemical markers of bone turnover, and calcium.


Bone markers in the management of patients with skeletal metastases

Jul 15, 2002 ... BACKGROUND. Biochemical markers of bone remodeling have been used as surro- ... bone disease. Recently discovered markers of osteoclastogenesis, osteoprotegerin. (OPG) and the soluble form of the receptor activator for nuclear factor (NF)-κB ..... ers: biochemical and clinical perspectives. London: ...


Markers of Bone and Collagen Metabolism – Problems and

of skeletal growth, however, bone metabolism differs considerably between children and adults. Thus, there is a specific paediatric perspective of bone metabolism and of the biochemical parameters used in its evaluation. While the molecular basis and clinical use of markers of bone metabolism in adult medicine has.


Immediate Fall of Bone Formation and Transient Increase of Bone

Glucocorticoid (GC)-induced osteoporosis is the leading form of secondary osteoporosis. Bone loss can be rapid. However, longitudinal studies at the very beginning of treatment are scarce. Patients relapsing from multiple sclerosis are treated with high-dose, short-term iv GCs. A number of them are young, without ...


Markers of bone turnover for the prediction of fracture risk and

Nov 8, 2010 ... of biochemical markers of bone turnover in the selection and monitoring of bisphosphonate treatment in osteoporosis. 2009. Canada. “Potential clinical uses of BTMs include prediction of bone loss and fracture in untreated postmenopausal women, to monitor osteoporosis therapy, and perhaps to enhance ...


Pediatric reference intervals for biochemical markers: gaps and

are incomplete and may be inappropriate for clinical use. The use of ... for pediatric populations based on specific age- and. Corresponding author: Khosrow Adeli, Ph.D., FCACB, DABCC. Clinical Biochemistry. Pediatric Laboratory Medicine. The Hospital for Sick .... pediatrics including bone markers [ 5], cardio- vascular ...


The Changes of Bone-Specific Alkaline Phosphatase (BsALP

(BsALP) as a biochemical parameter in the early posttraumatic phase may indicate the speed of fracture healing. The evaluation ... sion that by monitoring the changes of biochemical parameters: alkaline phosphatase and bone-specific alcaline ..... (Eds.), Bone Markers: Biochemical and Clinical Perspectives,. Martin Dunitz ...


Perspective: Assessing the Clinical Utility of Serum CTX in

Feb 16, 2009 ... article presents an overview of the current literature regarding critical issues affecting the clinical utility of. BTMs (including ... form new bone.(2) Biochemical bone turnover markers. (BTMs) are released during bone remodeling and can provide a measure of the rate of bone metabolism. They comprise ...


Cancer Treatment-Induced Bone Loss: Pathophysiology and

Nov 10, 2007 ... Cancer Treatment-Induced Bone Loss: Pathophysiology and. Clinical Perspectives. ADAM M. BRUFSKY. University of Pittsburgh School of Medicine, Magee-Women's Hospital, Pittsburgh, Pennsylvania, USA. Key Words. Androgen deprivation therapy • Aromatase inhibitor • Bisphosphonate • Bone loss • ...


Laboratory reproducibility of biochemical markers of bone turnover

Jun 9, 2009 ... clinical specimens. This study aimed to determine the laboratory reproduc- ibility of two biochemical markers of bone turnover: urine cross-linked N-telopeptide of type I collagen (NTX), a marker of bone resorption, and serum bone-specific alkaline phosphatase (BAP), a marker of bone formation. Methods.


Low bone mineral density in men with chronic obstructive pulmonary

BMD, forced expiratory volume in one second (FEV1), circulating bone biomarkers and biochemistry were determined in 30 clinically stable male ex- smokers with ... Bone biomarkers suggest increased bone turnover. ...... Eastell R, Baumann M, Hoyle NR, Wieczorek L: Bone markers: Biochemical and Clinical Perspectives.


Serum Concentrations of Cross-Linked N-Telopeptides of Type I

as bone resorption markers, and those of bone alkaline phosphatase (BAP) and intact osteocalcin (OC) as bone ... Japan for clinical use as a bone resorption marker. Im- paired urinary excretion precludes urinary ... biochemical bone markers were measured in the same assay run 1 year after sample collection. Although ...


Exendin4, a GlucagonLike Peptide1 Receptor Agonist, Prevents

propeptide of type 1 procollagen (P1NP) levels, key biochemical markers of bone turnover. Interestingly ... showed that exendin‐4 not only inhibited bone resorption by increasing the osteoprotegerin (OPG)/receptor activator of NF‐kB ligand. (RANKL) ratio ... exert their clinical effect by decreasing the rate of bone resorption ...


Experimental osteonecrosis: development of a model in rodents

Dec 17, 2015 ... Pagani F, Francucci CM, Moro L. Markers of bone turnover: biochemical and clinical perspectives. J Endocrinol Invest. 2005;28(Suppl 10):8-13. 29. Ayranci F, Gungormus M, Omezli MM, Gundogdu B. The effect of alendronate on various graft materials used in maxillary sinus augmentation: a rabbit study.


Protein phosphatase activities in the serum and saliva of healthy

cystic fibrosis. Clin Chim Acta 1984;143(2):135-45. 23. Pagani F, Francucci CM, Moro L. Markers of bone turnover: biochemical and clinical perspectives. J Endocrinol Invest. 2005;28(10 Suppl):8-13. 24. Pater A, Sypniewska G, Pilecki O. Biochemical markers of bone cell activity in children with type 1 diabetes mellitus. J.


Analysis of the Influence of Hormone Replacement Therapy on

Sep 9, 2014 ... Clinical Study. Analysis of the Influence of Hormone Replacement Therapy on. Osteocalcin Gene Expression in Postmenopausal Women ... of bone resorption. Constant reconstruction of bone tissue is known as remodeling. There are biochemical markers which may be used during the process of ...


Value of biomarkers in osteoarthritis: current status and perspectives

Jul 29, 2013 ... and perspectives. M Lotz,1 J Martel-Pelletier,2 C Christiansen,3 M-L Brandi,4 O Bruyère,5 R Chapurlat,6. J Collette,7 C Cooper,8,9 G Giacovelli,10 J A Kanis,11 ... convened to discuss the value of biochemical markers of ...... 7Department of Clinical Chemistry, Bone and Cartilage Markers Laboratory, CHU,.


CLINICAL PERSPECTIVE Acromegaly and Cancer: Not a Problem?

tered markers of colon epithelial cell proliferation (37). Colon polyps in acromegaly. Over the years, numerous ... Although both models exhibit biochemical and clinical fea- tures characteristic of acromegaly, no renal or ... thyroid, brain, bone, and hematologic system with acromeg- aly. In largely selective retrospective and ...